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Frederick Sisson died 9/1792 in Edgefield County. He had an early land grant in Edgefield County (then Granville) of land on the Little Saluda River. LWT dated 3/5/1792, probated September Term 1792. He married twice. Stepsons: Martin Smith and Wyly Smith. Children:
- Allethea Sisson
- Pamelia Sission
- William Sisson
- child in esse at father's death